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Aspartame – The Bittersweet Reality

Aspartame The Discovery… Aspartame was discovered in 1965 by an international pharmaceutical company, G.D. Searle and Company. A group working on an ulcer drug were looking for an inhibitor of the gastrointestinal secretory hormone gastrin. While creating a bioassay (potency of a substance by its effect on living cells or tissues) an intermediate chemical was synthesized, aspartylphenylalanine-methyl-ester (aspartame). While
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